Here is what you want for a space-time:
Hausdorff (so that you have uniqueness of limits of sequences and of functions with values in your manifold), paracompact (so that you can have a partition of unity, without which much of the global analysis will be impossible).
Locally homeomorphic to ${\mathbb R}^n$ (most of the time, $n=4$). However, in fact, you will need more, see Part 4 below. Part 2 will imply 1st countable.
1 + 2 imply metrizable, which is stronger than normal and the latter is stronger than regular. Conversely, every metrizable space which is locally homeomorphic to ${\mathbb R}^n$, is paracompact and Hausdorff.
- Frequently, you'd want your space-time to be connected (same as path-connected, subject to Assumption 2). Most of the time, you will not want to assume compactness. Compactness would exclude such basic examples as ${\mathbb R}^{3,1}$ and products of a 3-dimensional manifold with ${\mathbb R}$.
1+2+3 will imply 2nd countable and separable. Sometimes, connected is too much, you would want at most countably many connected components. (Connected means exactly one connected component.) 1+2+2nd countable will imply paracompact with at most countably many connected components.
This takes care of almost everything on your list except for "metric." Metric (in topology) means a "distance function" $d(\cdot, \cdot)$ consistent with topology:
$\lim_{i\to\infty} p_i=p$ for a sequence in your manifold if and only if $\lim_{i\to\infty} d(p_i,p)=0$.
Most of the time, you do not want to fix such distance function in advance, you just want to know that it exists (which means "metrizable").
Definition. A topological manifold is a topological space satisfying 1 and 2 (some form of 3 is optional, for some arguments, you want 2nd countable, for other arguments, paracompact is good enough). Personally, I prefer to assume 2nd countable.
- However, this is not all: You want to be able to "do geometry and analysis" on your manifold, which means that you want more than just a topological manifold defined above. In GR you want to be able to talk about a Lorentzian (signature $(n-1,1)$) metric (not a distance function!) on your manifold. For that, you have to require your manifold to be given a smooth structure (an atlas with smooth transition maps). You can think of such a structure as a strengthening of item 2 above. A topological manifold together with a chosen smooth structure is called a smooth manifold. This is what you really want for your space-time.
Remark. You also want to have a smooth structure if you are doing QFT: You want to be able to work with bundles, connections, curvature, etc, which will require some degree of smoothness.
Not every smooth manifold admits a Lorentzian metric (for instance, the 4-dimensional sphere does not). The necessary and sufficient condition for the existence of a Lorentzian metric on a smooth manifold $M$ is:
Every component of $M$ is either noncompact or has zero Euler characteristic.
Now, one can define a (classical) spacetime as:
A smooth 4-dimensional manifold $M$ equipped with a Lorentzian metric (i.e. a semi-Riemannian metric of signature $(3,1)$).
Since you do not mind a redundant answer: Every such $M$ will be Hausdorff, regular, normal, metrizable, separable, 1st countable, paracompact, 2nd countable, have at most countably many (path) connected components. However, in general, it will be neither connected nor compact.