This post is inspired by this one. I have two related questions.
Definition. Let $n$ be a positive integer. For an integer $m$ and $a$, we say that $a$ is an $n$-th power residue modulo $m$ if $$x^n\equiv a\pmod{m}$$ has a solution $x\in\mathbb{Z}$. A subset $S\subseteq \mathbb{Z}$ is said to be $n$-th power saturated if, for each prime natural number $p$, $S$ contains an $n$-th power residue modulo $p$.
Examples. The set of all prime natural numbers itself is $n$-th power saturated for every positive integer $n$. The set $\{2,3\}$ is not $n$-th power saturated for $n\in\{2,3,4\}$ (i.e., it is not quadratic-saturated, cubic-saturated, or quartic-saturated).
Question 1. For each positive integer $n$, what is the smallest cardinality of an $n$-th power saturated subset $S$ of the set of positive integers $\mathbb{Z}_{>0}$ such that
(a) $S$ contains no $n$-th perfect powers? (Let the answer be $A_n$.)
(b) $S$ contains no perfect powers at all? (Let the answer be $B_n$.)
(c) $S$ contains only squarefree integers? (Let the answer be $C_n$.)
Question 2. Does there exist a finite set $S$ containing integers greater than $1$ such that $S$ is $n$-th power saturated for any positive integer $n$?
Update. The answer is no. See Carl Schildkraut's answer below.
Known Results. Obviously, $$A_n\leq B_n\leq C_n\,.$$ From this answer, we know that $$C_n\leq \dfrac{n(n+1)}{2}\,.$$ It is known that $$A_2=B_2=C_2=3$$ due to Chebotarev's Theorem. (I have not seen a proof of this claim about the case $n=2$, so a reference for this would be appreciated.) From user760870's comment below, we can see that $$B_4\leq 6\,,$$ by taking $S=\{2,3,6,12,18,24\}$. The same user claimed in the same comment that $$A_n=B_n=n+1\text{ if $n$ is prime}\,,$$ with $S=\{2,3,6,12,\ldots,3\cdot 2^{n-1}\}$ as an example (I understand why this choice of $S$ works, but I cannot yet prove that this set $S$ has the lowest possible cardinality). It is easy, however, to verify that $$A_{8}=1\,,$$ by taking $S=\{16\}$, per the comment by user760870. Consequently, $$A_{2^k}=1\text{ for all }k=3,4,5,\ldots\,,$$ by taking $S=\left\{2^{2^{k-1}}\right\}$.
This is a proof that $A_8=1$, where $S=\{16\}$ works. Note that $$x^8-16=(x^2-2)(x^2+2)(x^4+4)\,.$$ - If $p=2$, then $x=0$ is a trivial solution.
- If $p\equiv 1 \pmod{8}$ or $p\equiv 7\pmod{8}$, then $x^2-2\equiv 0\pmod{p}$ has a solution $x\in\mathbb{Z}$.
- If $p\equiv 3\pmod{8}$, then $x^2+2\equiv 0\pmod{p}$ has a solution $x\in\mathbb{Z}$.
- If $p\equiv 5\pmod{8}$, then let $t\in\mathbb{Z}$ satisfy $t^2+1\equiv0\pmod{p}$, and note that $2t$ is a quadratic residue modulo $p$ (since both $2$ and $t$ are not). Therefore, $x^2-2t\equiv 0\pmod{p}$ has a solution $x\in\mathbb{Z}$, whence $$x^4+4\equiv (x^2-2t)(x^2+2t)\pmod{p}$$ implies that $x^4+4\equiv0\pmod{p}$ has a solution $x\in\mathbb{Z}$.
From this result, we can then conclude that $A_{2^k}=1$ with $S=\left\{2^{2^{k-1}}\right\}$, where $k\geq 3$ is a positive integer. This is because $x^{2^k}-2^{2^{k-1}}$ is divisible by $x^8-16$. In fact, $$x^{2^k}-2^{2^{k-1}}=(x^2-2)\,\prod_{j=1}^{k-1}\,\left(x^{2^j}+2^{2^{j-1}}\right)=(x^8-16)\,\prod_{j=3}^{k-1}\,\left(x^{2^j}+2^{2^{j-1}}\right)\,.$$