First note that
$$2.2 = 11/5 <\sqrt{5} < 9/4 = 2.25.$$
You can prove this by showing that $(11/5)^2$ is less than $5$, and that $(9/4)^2$ is more than $5$.
Now we estimate $2^{2.25}$, by showing that it is less than $5$. To do this, we raise both sides of the inequality $2^{9/4} < 5$ to the power of $4$ to obtain an equivalent inequality, namely
$$2^9 < 5^4.$$
Since this inequality is easily checked, we've proved that $2^{2.25} < 5$.
Finally we estimate $2^{2.2}$, by showing that it is more than $4.5$. The inequality
$$2^{11/5} > 9/2$$
is equivalent to the inequality obtained by raising both sides to the power of $5$:
$$2^{11} > (9/2)^5, \quad \text{ equivalent in turn to } 2^{16}>9^5.$$
The last inequality can be checked by hand.
Together, these calculations show that $2^{\sqrt{5}}$ is more than $4.5$, but less than $5$.