To derive the formulas for$~_n C_k=\binom{n}{k}$ using the definition that $\binom{n}{k}$ represents the number of different $k$ element subsets out of a set of $n$ distinct elements where order does not matter, you may consider this a multiplication principle question.
Step 1: pick the first element to appear ($n$ choices), Step 2: pick the second element to appear ($n-1$ choices), ... Step $k$: pick the $k$th element to appear ($n-k+1$ choices).
Noticing then that we overcounted and for each "different" possibility, we have counted the possibility a total of $k!$ number of times (since those $k$ steps could have been done in any different order), we divide by the amount $k!$ to account for the symmetry involved.
Thus, $\binom{n}{k} = \dfrac{n\cdot(n-1)\cdot(n-2)\cdots(n-k+1)}{k!} = \dfrac{n!}{(n-k)!k!}$
As for the condition that $0\leq k\leq n$, note that there is no way to choose more things from our set than there exist elements in the set in the first place. Similarly, it doesn't make sense to take a negative amount of things from the set. Indeed, $m!$ is not defined for any negative integer $m$, and as such if $k$ is outside of the range $[0,n]$ then one of $k!$ or $(n-k)!$ would not be defined. In that case, we define $\binom{n}{k}$ to be $0$.