Suppose $M$ is a smooth submanifold of $\mathbb{R}^n$. Through some transversality tricks, I was able to prove that if $\dim M<n-2$, then $\mathbb{R}^n\setminus M$ is always connected and simply connected.
This motivates me to ask is it true that if $\dim M\geq n-2$, then $\mathbb{R}^n\setminus M$ is not connected and simply connected? Even looking at some small cases, if $\dim M=0$, say $M$ is a finite number of points, then although $\mathbb{R}^2\setminus M$ is connected, it is not simply connected since it retracts onto a wedge of circles. I was told does indeed follow from mod-$2$ intersection theory, but I don't see how to apply that here.