Let $M$ be a connected, compact, and orientable 3-manifold ($H^3(M)\cong\mathbb{Z}$), and let $G$ be a simple Lie group satisfying $\pi_1(G)=\pi_2(G)=0$. Let
$\pi_M(G)$ denote the set of homotopy classes of maps from $M\to G$
$\pi_3(G)$ denote the set of homotopy classes of maps from $\mathbb{S}^3\to G$
Suppose I have a map $f:M\to \mathbb{S}^3$ which induces an isomorphism on $H^3$, and for which $f_*:\pi_3(G)\to \pi_M(G)$ is surjective. $$f_*[g]:=[g\circ f]$$
Is this enough information to infer that $f_*$ is an isomorphism?