$$
x \frac{\partial u}{\partial x} + y \frac{\partial u}{\partial y} = \frac{2e^u }{xy } , x>0,y>0
$$
Let $u=-\ln(v)$
$$
-\frac{x}{v} \frac{\partial v}{\partial x} - \frac{y}{v} \frac{\partial v}{\partial y} = \frac{2 }{xy\:v }$$
$$x \frac{\partial v}{\partial x} + y \frac{\partial v}{\partial y} = -\frac{2 }{xy }$$
Let $x=e^X $ and $y=e^Y$
$$\frac{\partial v}{\partial X} + \frac{\partial v}{\partial Y} = -2e^{-X-Y}$$
The solution of the homogeneous PDE $\frac{\partial V}{\partial X} + \frac{\partial V}{\partial Y} =0$ is $V=f(X-Y)$, any derivable function $f$.
An obvious particular solution of $\frac{\partial v_p}{\partial X} + \frac{\partial v_p}{\partial Y} = -2e^{-X-Y}$ is $v_p=e^{-X-Y}$.
The general solution of $\frac{\partial v}{\partial X} + \frac{\partial v}{\partial Y} = -2e^{-X-Y}$ is :
$$v=f(X-Y)+e^{-X-Y}$$
$$v=f\left(\ln(x)-\ln(y)\right)+e^{-\ln(x)-\ln(y)}=f\left(\frac{x}{y}\right)+\frac{1}{xy}$$
And, coming back to $u(x,y)=-\ln(v)$ we obtain the general solution of the initial ODE $x \frac{\partial u}{\partial x} + y \frac{\partial u}{\partial y} = \frac{2e^u }{xy }$ :
$$u(x,y)=-\ln\left( f\left(\frac{x}{y}\right)+\frac{1}{xy}\right)$$
where $f$ is any derivable function.
It remains to take account to the boundary conditions in order to determine the function $f$.
Unfortunately, I do not understand anything of the wording about the boundary conditions. So, I cannot go further.
Supposing that the boundary condition is $x(s,t)=y(s,t)=s e^t$ and nothing else, then
$$u(s,t)=-\ln\left( f\left(\frac{s e^t}{s e^t}\right)+\frac{1}{s^2 e^{2t}}\right)$$
$f\left(\frac{s e^t}{s e^t}\right)=f(1)=$constant
$$u(s,t)=-\ln\left( C+\frac{1}{s^2 e^{2t}}\right)=\ln\frac{s^2}{C s^2+ e^{-2t}}$$
This equation is different from the equation given in the wording of the question. That is why I do not understand correctly the boundary conditions as they are defined.