Quite possibly I'll solve this and post my answer below, but maybe others will post better answers before I get to that. Or after.$^\dagger$
The group of permuations of $\{a,b,c,d,e,f\}$ is generated by $15$ elements of order $2$, each of which is a transposition like this one: $(a,b)$. For each such transposition there are eight others with which it overlaps, as in the case of $(a,b)$ and $(b,c)$, and six others with which it does not overlap, as in the case of $(a,b)$ and $(c,d)$. Composition of two that overlap yields a $3$-cycle, and composition of two that do not overlap yields an element of order $2$.
The group of permutations of $\{a,b,c,d,e,f\}$ is also generated by $15$ elements of order $2$, each of which is a composition of three transpositions like this one: $(ab)(cd)(ef)$. For each such generator there are eight others with which does not "overlap" in a different sense than that above, such as $(ac)(be)(df)$; "ovlerlapping" in this case would mean having a $2$-cycle in common; and there are six others with which it does "overlap", as in the case of $(ab)(cd)(ef)$ and $(ab)(ce)(df)$. Composition of two that do not overlap yields a composition of two $3$-cycles; composition of two that do overlap yields a composition of two $2$-cycles.
The above is the beginning of the fact that a certain kind of bijection from the first set of $15$ generators to the second extends to an outer automorphism of the group of all $720$ permutations of $S_6$.
So I looked at certain compositions of three generators. Composing from left to right: \begin{align} (ab)(ac)(ad) & = (abcd) \\ (ab)(ac)(ae) & = (abce) \\ (ab)(ac)(af) & = (abcf) \\[10pt] (ab)(ac)(bc) & = (ac) \end{align}
- Given the first two overlapping in $a$, there are three choices of a third one overlapping in $a$, and in each case the result is a $4$-cycle. There is only one choice of a generator overlapping with both in a different way, and the result is another generator.
So I asked myself: what fact about the second set of generators corresponds with the bulleted paragraph above? Given two generators that do not overlap, we should expect four possible choices of a third one that does not overlap either of them; in three cases the composition of the three should yield an element of order $4$ and in one case an element of order $2$ that is one of the $15$ generators. When the matter is expressed in that way, it's not hard to find them: \begin{align} \Big((ab)(cd)(ef)\Big)\Big((ac)(be)(df)\Big)\Big((ad)(bf)(ce)\Big) & = (acbe) \\ \Big((ab)(cd)(ef)\Big)\Big((ac)(be)(df)\Big)\Big((ae)(bd)(cf)\Big) & = (bfde) \\ \Big((ab)(cd)(ef)\Big)\Big((ac)(be)(df)\Big)\Big((af)(bc)(de)\Big) & = (adfc) \\[10pt] \Big((ab)(cd)(ef)\Big)\Big((ac)(be)(df)\Big)\Big((af)(bd)(ce)\Big) & = (ac)(be)(df) \end{align} So we should have another bulleted paragraph paralleling the one above:
- Given the first two non-overlapping pairs of generators, there are three choices of a third one not overlapping with them in such a way that the result is a $4$-cycle. There is only one choice of a generator failing in a different way to overlap with both, and the result is another generator.
But (and this is my question!) what does "failing in a different way to overlap with both" mean? $$\begin{array}{cccccccc} \phantom{------------------------} \\ \hline \end{array}$$ $\dagger$ I have now posted my own answer, but maybe someone has some insights that I don't have.