The axis of symmetry is indeed the $x$-axis. We note that $1/2 = 1/(2 \cdot 1)$ and $1/5 = 1/(2 \cdot 2.5)$; this yields the guess
$$
x = y^2+1
$$
which satisfies each of the conditions.
ETA: More generally, if we disregard the hint about the axis of symmetry, we consider the general form of the parabola (with some parameters adjusted from the usual form for the sake of convenience):
$$
(Ax+Cy)^2 + Dx + Ey + F = 0
$$
Plugging in the two points $(2, 1)$ and $(7.25, 2.5)$ gives us
$$
(2A+C)^2 + 2D + E + F = 0
$$
$$
(7.25A+2.5C)^2 + 7.25D + 2.5E + F = 0
$$
Implicit differentiation gives us
$$
2(Ax+Cy)\left(A+C\frac{dy}{dx}\right) + D + E\frac{dy}{dx} = 0
$$
or
$$
\frac{dy}{dx} = - \frac{2A(Ax+Cy)+D}{2C(Ax+Cy)+E}
$$
which produces
$$
4AC+2C^2+E = -8A^2-4AC-2D
$$
$$
14.5AC+5C^2+E = -72.5A^2-25AC-5D
$$
We therefore have four equations in five unknowns. Although it's easy to see that $A = E = 0, C = F = 1, D = -1$ is a solution, there may be others if we ignore the hint about the axis of symmetry.
We consider two cases.
Case I. Suppose $A = 0$. Then, without loss of generality, $C = 1$, and our equations are
$$
1+2D+E+F = 0
$$
$$
6.25+7.25D+2.5E+F = 0
$$
$$
2+E = -2D
$$
$$
5+E = -5D
$$
Clearly, $D = -1, E = 0, F = 1$, and $y^2-x+1 = 0$ is the only solution.
Case II. Let $A \not= 0$, then without loss of generality, $A = 1$, and we have
$$
(2+C)^2+2D+E+F = 0
$$
$$
(7.25+2.5C)^2+7.25D+2.5E+F = 0
$$
$$
2C^2+8C+2D+E+8 = 0
$$
$$
5C^2+39.5C+5D+E+72.5 = 0
$$
which has the solution $C = -3.5, D = 3, E = -10.5, F = 2.25$ when $A = 1$, or in integers, we have $(2x-7y)^2+12x-42y+9 = 0$ as another solution. However, this can be rewritten as $(2x-7y)^2+6(2x-7y)+9 = 0$, or $2x-7y = -3$. This is a degenerate parabola—a line (the implicit form of the derivative yields an indeterminate $0/0$)—so $x = y^2+1$ is indeed the only solution.