This is more of an extended comment than an answer, but with regards to typesetting in $\LaTeX$, let me point out that typing \mathrm{d} should not take longer than typing d, as you shouldn't be doing either throughout your paper!
The semantically correct thing to do is to define a macro representing your desired differential operator, for example, \newcommand{\dv}[1]{\frac{\mathrm{d}}{\mathrm{d} #1}}. Then, whenever you need to typeset $\frac{\mathrm{d}}{\mathrm{d}x}$ or $\frac{\mathrm{d}}{\mathrm{d}t}$, you simply use \dv{x} or \dv{t}, which is even easier than the non-standards-conforming \frac{d}{dx}.
This has the added benefit that, should you find yourself submitting to a publisher whose house style requires italic $d$'s, you need only change the definition of your macro instead of modifying every differential operator by hand.