Here is a non-calculus approach to find the minimum.
By completing the square we get
$$
\begin{align}
f(x_1,x_2)&=4x_1^2+2x_2^2-4x_1x_2-8x_2\\
&=4\left(x_1-\frac{x_2}2\right)^2+x_2^2-8x_2\\
&=4\left(x_1-\frac{x_2}2\right)^2+(x_2-4)^2-16\\
&=(2x_1-x_2)^2+(x_2-4)^2-16
\end{align}
$$
After the substitution $y_1=2x_1-x_2$ and $y_2=x_2-4$ we transform
this to the problem to minimize
$$g(y_1,y_2)=y_1^2+y_2^2-16$$
for
$$y_1+3y_2\le -4.$$
This is the same question as finding the point on the line
$y_1+3y_2=-4$, which is closest to the origin. Geometrically we can
see that this point must belong to the perpendicular line $3y_1-y_2=0$
and we get $y_1=-\frac25$, $y_2=-\frac65$ with $g(y_1,y_2)=\frac4{25}+\frac{36}{25}-16=\frac85-16=-\frac{72}5$.
This corresponds to $x_1=\frac65$ and $x_2=\frac{14}5$.
WolframAlpha yields the same result.