The question as stated cannot be answered without additional information, such as information about the boundary.
Two standard approaches to uniqueness of $C^2$ solutions to Poisson's equation are the maximum principle and energy estimates, both of which rely on a bounded domain and a reasonably regular boundary. Without information on the boundary of the domain you will need a new method.
Moreover, in most situations uniqueness fails rather explicitly without boundary conditions. For example, in the case of the homogeneous equation $\Delta u = 0$, with no assumptions on the boundary there is always the trivial solution, while for the inhomogeneous equation $-\Delta u = f$ you can always construct a new solution by adding a solution of the homogeneous equation if you don't care about the boundary conditions. In fact, for the homogeneous equation you will have an infinite-dimensional vector space of solutions (say, a subspace of $C^2$), and for the inhomogeneous equation you can get an infinite-dimensional affine subspace.
Finally, even if you specify boundary conditions uniqueness may fail. For example, for the homogeneous equation $\Delta u = 0$ on the half-space $\mathbb{R}_+^n$, you will obtain uniqueness only for bounded solutions of the boundary-value problem. (This argument is actually pretty nice: if $u$ is bounded, harmonic, and $u=0$ on the boundary of the half-space, you can reflect $u$ across the boundary to obtain a bounded harmonic function.) If on an unbounded domain you do not specify behavior at infinity, you may lose uniqueness: for example, for the boundary-value problem
$$
\begin{cases}
\Delta u = 0 & |x|\geq 1\\
u=0 & |x|=1
\end{cases}
$$
in $\mathbb{R}^n\setminus B_1(0)$, in dimension $n=2$ the functions $u(x) = a\log|x|$, $a$ any constant, are solutions. Adding the assumption that $u(x)$ is bounded restores the uniqueness for $n=2$. In $n=3$, the functions $u(x) = a(1-|x|^{-1})$ are solutions for any constant $a$. So again we lose uniqueness to the BVP; asserting that $u(x)$ tends to a limit as $|x|\to\infty$ restores the uniqueness.