YES, we can show that a formula $\varphi$ is not valid through a semantic tree, considering its negation $\lnot \varphi$.
If the tree does not close, then $\lnot \varphi$ is satisfiable and thus $\varphi$ is not valid.
1) $(∃x)A ∧ (∃x)B$
2) $\lnot (∃x)(A ∧ B)$ --- 1) and 2) using the rule for $\lnot (\to)$
3) $(∃x)A$
4) $(∃x)B$ --- from 1) using the rule for $(\land)$
5) $Aa$ --- from 3) using the rule for $\exists$ : $a$ new
6) $Bb$ --- from 4) using the rule for $\exists$ : $b$ new
Now we have to apply the rule for $\lnot (\exists)$ to 2) for all the parameters already used in the tree : $a$ and $b$ :
7) $\lnot (Aa ∧ Ba)$
8) $\lnot (Ab ∧ Bb)$
Now we have to apply the rule for $\lnot (\land)$ to both 7) and 8), producing three branches, from left to right :
$9_L$) $\lnot Aa$ --- from 7) : this branch closes with 5)
$9_R$) $\lnot Ba$ --- from 7)
$10_L$) $\lnot Ab$ --- from 8)
$10_R$) $\lnot Bb$ --- from 8) : this branch closes with 6).
We have finished and we are left with an open path : 5), 6), $9_R$) and $10_L$).
This path defines an interpretation satisfying the formula $\lnot \varphi$ :
$Aa, \lnot Ab, \lnot Ba, Bb$
and thus providing a counter-example showing that $\varphi$ is not valid.
To verify it, consider that $Aa \land Bb$ sohws that $(∃x)A ∧ (∃x)B$ is true in this interpretation, while $Aa \land \lnot Ab$ and $\lnot Ba \land Bb$ show that $(∃x)(A ∧ B)$ is false in it.