Define $\partial f=-i\tilde{f}'$ on the domain $\mathcal{D}(\partial)$ consisting of $f\in L^2$ that is equal a.e. to an absolutely continuous $\tilde{f} \in L^2$ for which $\tilde{f}' \in L^2$.
Define $Mf = sf(s)$ on the domain $\mathcal{D}(M)$ consisting of all $f \in L^2$ for which $sf(s) \in L^2$.
Then the Fourier transform establishes a unitary equivalence between $\partial$ and $M$. That is, in the strictest operator sense,
$$
\partial = \mathcal{F}^{-1}M\mathcal{F}.
$$
More precisely, $\mathcal{F}\mathcal{D}(\partial)=\mathcal{D}(M)$ (equivalently, $\mathcal{D}(\partial)=\mathcal{F}^{-1}\mathcal{D}(M)$,) and the above holds on $\mathcal{D}(\partial)$. The operator $\partial$ is selfadjoint in the strictest sense, which implies two facts:
- The operator $\partial$ is symmetric:
$$
(\partial f,g) = (f,\partial g),\;\;\;f,g\in\mathcal{D}(\partial).
$$
- The adjoint is equal to itself. That is, $g\in\mathcal{D}(\partial)$ iff there exists $h\in L^2$ such that
$$
(\partial f,g) = (f,h),\;\;\;f\in\mathcal{D}(\partial).
$$
In that case, $g \in\mathcal{D}(\partial)$ and $\partial g = h$ a.e..
Therefore, $s^{n}\hat{f}(s) \in L^2$ iff $f \in \mathcal{D}(\partial^n)$ and, in that case,
$$
\mathcal{F}(\partial^{n}f) = s^{n}\mathcal{F}(s).
$$
In effect, the integration by parts evaluation terms at $\pm\infty$ vanish.
These are consequences of the Spectral Theorem applied to the selfadjoint operator $\partial$. Though a little surprising, $s^{n}\hat{f}(s)\in L^2$ iff $f$ has $n-1$ continuous derivatives in $L^2$ and $f^{(n-1)}$ is equal a.e. to an absolutely continuous function in $L^2$ for which $f^{(n)} \in L^2$. There is nothing nearly so nice in any other $L^p$.