Truth cannot be defined precisely. Mathematically, you can only define provability, which is whether a statement in some precise language can be derived in a sequence of steps from axioms according to some fixed deductive rules. If you decide to use a different language or axioms or rules, you would of course get a different collection of provable statements. The language, axioms and rules together form a formal system.
Whether one formal system is more 'true' than another leaves the realm of mathematics and goes into science and philosophy. Science, because we could define 'truth' as what is true in the real world, and some of these truths can possibly be empirically verifiable to some extent. Philosophy, because one has to make some initial assumptions anyway, such as that there is actually a real world...
But at least for this definition of truth based on the real world, it is not impossible that in the future someone might empirically verify some real world fact that contradicts the standard interpretation of some mathematical theorem. In that case, we would know that our mathematical model of the world is flawed, and examine to see what other theorems would be invalidated as well.
Historically, there was naive set theory that was proven to be inconsistent, which implies that every statement of naive set theory can be proven, both it and its negation, and so technically one could say that 'half' of all provable theorems would be false, regardless of whatever interpretation we choose. That was 'fixed' by modifying the axioms of set theory, so now we have ZF[C]. As of today mathematicians have proven a lot of statements in ZFC, so it is conceivable that if ZFC turns out to be inconsistent, then we might find that two of the published theorems contradict one another, in which case we would have to decide which one to reject. However, most mathematicians believe that ZFC is consistent.