The points A, B, C and D, in this particular order, lie on a circle. The chords AC and BD intersect in the point P, the line through $C$ perpendicular to AC and the line through $D$ perpendicular to BD intersect in the point Q.
How do you prove that the line AB and PQ are perpendicular to one another?
NOTE: the chords do not have to be perpendicular to one another!
Note
The following image makes both lines evidently nontangent to the circle. OP's last drawing makes the line perpendicular to BD seem tangent. Thanks GeoGebra :).

