$y=\dfrac{ax^2 + bx + c}{dx+e}$
can be rewritten as
$ax^2 - dxy + 0y^2 + bx + ey + c = 0$
which is known to be the equation of a conic section.
Comparing this to $Ax^2 + Bxy + Cy^2 + Dx + Ey + F$
we compute the descriminant to be
$B^2 - 4AC = d^2 \gt 0$.
This implies that you have the equation of a hyperbola. Hence it will have two axis of symmetry.
addendum
$y=\dfrac{ax^2 + bx +c}{dx+e}$
\begin{array}{ccccccc}
&&&& \dfrac adx &+& \dfrac{bd-ae}{d^2}\\
& &--&--&---&-&-----\\
dx + e&|&ax^2 &+& bx &+& c\\
& &ax^2 &+& \dfrac{ae}{d}x \\
& &---&-& -----\\
& && &\dfrac{bd-ae}{d}x &+& c \\
& && &\dfrac{bd-ae}{d}x &+& \dfrac{bde-ae^2}{d^2} \\
& && &-----&-&-------\\
& &&&&& \dfrac{cd^2 - bde + ae^2}{d^2} \\
\end{array}
We find
$y = \dfrac adx + \dfrac{bd-ae}{d^2} + \dfrac{cd^2 - bde + ae^2}{d^2(dx+e)}$
Which admits to the vertical asymptote $dx + e = 0$ and the slant asymptote
$adx-d^2y + (bd - ae) = 0$
The two asymptotes intersect at the point
P = $\left(-\dfrac ed, \dfrac{bd - 2ae}{d^2}\right)$.
The change of coordinates
\begin{array}{l}
x = u - \dfrac ed\\
y = v + \dfrac{bd - 2ae}{d^2}
\end{array}
translates the point $(x,y) = P$ to the point $(u,v) = (0,0)$
The asymptotes become $u = 0$ and $au -dv = 0$
The two axis of symmetry are the two lines that bisect the vertical angles formed by the two asymptotes. Their equations are described by
\begin{align}
|u| &= \dfrac{|au-dv|}{\sqrt{a^2+d^2}} \\
au - dv &= \mp \sqrt{a^2 + d^2}\;u \\
(a \pm \sqrt{a^2 + d^2})u - dv &= 0 \\
v &= \dfrac{a \pm \sqrt{a^2 + d^2}}{d} u
\end{align}
Translating back into $(x,y)$ coordinates, we get
\begin{align}
y - \dfrac{bd - 2ae}{d^2}
&= \dfrac{a \pm \sqrt{a^2 + d^2}}{d}(x + \dfrac ed) \\
y- \dfrac{bd - 2ae}{d^2} &= \dfrac{a \pm \sqrt{a^2 + d^2}}{d}x
+ \dfrac{e(a \pm \sqrt{a^2 + d^2})}{d^2}\\
y &= \dfrac{a \pm \sqrt{a^2 + d^2}}{d}x
+ \dfrac{-ea + bd \pm e\sqrt{a^2 + d^2})}{d^2}
\end{align}
So the two axis of symmetry are
$$y = \dfrac{a + \sqrt{a^2 + d^2}}{d}x
+ \dfrac{-ea + bd + e\sqrt{a^2 + d^2})}{d^2}$$
and
$$y = \dfrac{a - \sqrt{a^2 + d^2}}{d}x
+ \dfrac{-ea + bd - e\sqrt{a^2 + d^2})}{d^2}$$