I'm only interested in the case where $A$ is a single point and $X=S^2$ for the following question from Hatcher's book on Algebraic Topology.
Question: Compute the homology of groups $H_n(X,A)$ when $X$ is $S^2$ or $T^2$ and $A$ is a finite set of points in $X$.
Answer Attempt: In Hatcher p.g. 117 it says you can think of the relative homology $H_n(X,A)$ as the measure of the difference between the two groups $H_n(X)$ and $H_n(A)$. Taking that literally, let $x\in X$, then $H_n(S^2\setminus {x})\cong H_n(\mathbb{R^2})\cong 0$
EDIT: Actually, if I were to take the statement, "you can think of the relative homology $H_n(X,A)$ as the measure of the difference between the two groups $H_n(X)$ and $H_n(A)$.", from Hatcher literally it would be more correct to note that since $H_2(X)\cong \mathbb{Z}$ and $H_2(A)=H_1(A)=0$ their difference is $\mathbb{Z}$.