Assuming the title question should refer to $ax^2+bx+c$:
That expression describes a concave-upward parabola (an upright U-shape, in other words). Its lowest point is therefore at the vertex of the parabola; you may recall that its $x$-coordinate is $-\frac{b}{2a}$ (which accounts for that fraction's appearance in the quadratic formula), and therefore the $y$-coordinate is what comes out when you plug $x = -\frac{b}{2a}$ into $ax^2+bx+c$.
For instance, if we consider the specific case $x^2-4x+9$, the vertex has an $x$-coordinate of $-\frac{-4}{2\cdot1} = 2$, and its $y$-coordinate is therefore $(2)^2-4(2)+9 = 5$. Now you just need to generalize for $a, b, c$.