Here is a way to see that
$$
\sum_{k=0}^{n} {2n+1 \choose k} = 2^{2n},
$$
by a counting argument which counts the number of subsets of $\{1, \ldots, 2n\}$ rather than half the number of subsets of $\{1, \ldots, 2n, 2n+1\}$. Essentially to count the subsets of $\{1, \ldots, 2n\}$, we break the subsets into whether or not their size is at most $n$.
Now to choose a subset, $B$, of $\{1, \ldots, n\}$, for some $0 \leq k \leq n$, we choose $k$ elements of $\{\star, 1, 2, \ldots, 2n\}$ getting a subset $A$. If $\star$ is not in $A$, then set $B=A$. If $\star$ is in $A$, then set $B=\{1, \ldots, 2n\} \setminus A$. Now the number of ways to choose our set $A$ is precisely
$$
\sum_{k=0}^{n} {2n+1 \choose k}.
$$
What remains is to show a 1-1 correspondence between the sets $A$ and subsets of $\{1, 2, \ldots, 2n\}$.
First, let us show that the correspondence between sets $A$ and subsets $B$ is onto. If $B$ is a subset of $\{1, \ldots, 2n\}$, then if $|B| \leq n$, we can let $A=B$; but if $|B| \geq n+1$, then we set $A=\{\star\} \cup \left( \{1, \ldots, 2n\}\setminus B\right)$ [now $|A| = 1+2n-|B| \leq n.$] Either way, this $A$ would give rise to our subset $B$.
Conversely, let us show that this correspondence is injective. Suppose $A$ and $A'$ both correspond to subset $B=B'$. Now if either $A$ and $A'$ both contain $\star$ or $A$ and $A'$ both do not contain $\star$, then clearly we must have $A=A'$. Suppose $A$ contains $\star$ but $A'$ does not. However,
\begin{align*}
|B| = 2n-(|A|-1) = n+1 +(n-|A|) &\geq n+1 \\&> n \geq |A'|=|B'|.
\end{align*}