A general idea: convert everything to exponential form. "Apples-to-apples." (Plus, things are much easier to manipulate and recognize from there.)
Let us see how that would go.
First attempt:
$$
\left(1+\frac{4\ln t_n}{t_n}\right)^{t_n}
= e^{t_n \ln\left(1+\frac{4\ln t_n}{t_n}\right) }
$$
Now, if remembering the useful inequalities $\ln(1+u)\leq u$,
you get
$$
\left(1+\frac{4\ln t_n}{t_n}\right)^{t_n}
\leq e^{t_n\frac{4\ln t_n}{t_n} } = e^{4\ln t_n } = t_n^4.
$$
On the other hand,
$$
16^{\ln t_n} = e^{\ln 16 \ln t_n} = t_n^{\ln 16}
$$
and $\ln 16 \simeq 2.77$. Sadly, this does not tell you immediately what you want (as for the first, we used an upper bound).
But we can improve a bit the first bound!
From
$$
\left(1+\frac{4\ln t_n}{t_n}\right)^{t_n}
= e^{t_n \ln\left(1+\frac{4\ln t_n}{t_n}\right) }
$$
we now use the fact that $\ln(1+u)=u+O(u^2)$ when $u\to 0$, and that $\frac{\ln t_n}{t_n}\xrightarrow[n\to\infty]{} 0$:
$$\begin{align}
\left(1+\frac{4\ln t_n}{t_n}\right)^{t_n}
&= e^{t_n \ln\left(1+\frac{4\ln t_n}{t_n}\right) }
= e^{t_n \left(\frac{4\ln t_n}{t_n}+O\left(\frac{\ln^2 t_n}{t_n^2}\right)\right) }
= e^{{4\ln t_n} +O\left(\frac{\ln^2 t_n}{t_n}\right) }\\
&= e^{{4\ln t_n} +o(1) }
= t_n^4\cdot e^{o(1) }
\end{align}$$
so this tells you immediately that $$\left(1+\frac{4\ln t_n}{t_n}\right)^{t_n} = \Theta(t_n^4) \tag{1}$$
while
$$16^{\ln t_n} = t_n^{\ln 16} < t_n^3 \tag{2}$$
since $t_n\xrightarrow[n\to\infty]{} \infty$ and $\ln 16 < 3$. Therefore,
$$
\left(1+\frac{4\ln t_n}{t_n}\right)^{t_n} = \omega\left(16^{\ln t_n}\right)
$$
when $n\to\infty$.