Consider for simplicity the case where $M$ can be covered by two coordinate charts $\phi_i \colon U_i \rightarrow M$. Then we only have a single non-trivial transition map $\phi_2^{-1} \circ \phi_1$ defined on $V = \phi_1^{-1}(\phi_1(U_1) \cap \phi_2(U_2)) \subseteq M_1$. The other transition maps are the identity maps $\phi_i^{-1} \circ \phi_i$ which have a positive Jacobian determinant and $\phi_1^{-1} \circ \phi_2$ which is the inverse of $\phi_2^{-1} \circ \phi_1$ and so the Jacobian determinants of $\phi_2^{-1} \circ \phi_1, \phi_2^{-1} \circ \phi_1$ have the same sign.
Assume first that $V$ is connected. Then we will have either $\det D(\phi_2^{-1} \circ \phi_1) > 0$ on the whole of $V$ and so the charts induce an orientation on $M$ or $\det D(\phi_2^{-1} \circ \phi_1) < 0$ on the whole of $V$. In the second case, by modifying one of the charts (say, by switching two coordinates or negating a coordinate) we can get an equivalent collection of charts for which $\det D(\phi_2^{-1} \circ \phi_1) > 0$ and so again an orientation.
However, if $V$ is not connected, then $\det D(\phi_2^{-1} \circ \phi_1)$ will have constant sign on each connected component of $V$ but in general, there isn't any modification we can do to one of the charts that will guarantee that $\det D(\phi_2^{-1} \circ \phi_1)$ will be positive. If $V$ has two connected components on which $\det D(\phi_2^{-1} \circ \phi_1)$ has different sign, then by modifying $\phi_i$ in the way described above will only switch the sign of the components.
In general, a conformal structure on a manifold is an equivalence class of Riemannian metrics and one can talk about conformal structures on non-orientable manifolds so you need to give more context so that your question makes sense.