I would be happy if one can help me with how to approach this problem.
Suppose that $K$ is a knot in $\mathbb{R}^3$, show that $\pi_1(\mathbb{R}^3 \setminus K)$ is isomorphic to $\pi_1(\mathbb{S}^3 \setminus K)$. I know I need to use Van-Kampen's Theorem to show the desired isomorphism, but I don't know how to choose $U$ and $V$. Thanks.