I assume you need exactly 4 girls together.
Hint 1: If you have 4 girls together, depending on where they are in the line you will need a boy on one side of them or the other or a boy on both sides. How many ways can you do this?
Answer 1: 5 ways with BGGGGB, 1 way with GGGGB, and 1 way with BGGGG. This means there are a total of $5+1+1=7$ ways to do this.
Hint 2: Once you have placed the 4 girls, where can the last girl go?
Answer 2: There 4 ways to place the last girl with BGGGGB and 5 ways for either GGGGB or BGGGG. Now there are $4\cdot 5+5\cdot 1+5\cdot 1=30\,\,$ ways to do all of this.
Hint 3: The first two hints should tell you how many different orderings of indistinguishable boys and girls there are (based on the work above, the answer is 30). So now if we fix an ordering of boys and girls, how many ways are there to place distinguishable boys and girls in the assigned positions?
Answer 3: There are $5!$ ways to place the girls and $5!$ to place the boys for a total of
$$
(5!)^2\cdot 30=432,000.
$$
Observe that
$$
\binom{6}{2}\cdot\binom{5}{4}\cdot4!\cdot2!\cdot5!=\frac{6\cdot 5}{2}\cdot5\cdot4!\cdot2!\cdot5!=30\cdot (5!)^2=432,000.
$$