I implemented a brute-force calculation for this problem. Unless I made a mistake, the count for $n = 2, 4, 6, 8$ is respectively 1, 6, 720, 16511040. I couldn't find a match in OEIS, so this leads me to suspect there is no simple answer.
My Mathematica code for the $n=8$ case (I was to lazy to code a function that works directly for any $n$, but it should be obvious how to generalize):
<< Combinatorica`
n = 8; X = Select[Involutions[n, Cycles], Length[#] == (n/2) &]; Sum[
Y = Select[X, Intersection[X[[i]], #] == {} &];
Sum[
Z = Select[Y, Intersection[Y[[j]], #] == {} &];
Sum[
W = Select[Z, Intersection[Z[[k]], #] == {} &];
Sum[
VVV = Select[W, Intersection[W[[l]], #] == {} &];
Length[VVV]
, {l, 1, Length[W]}]
, {k, 1, Length[Z]}]
, {j, 1, Length[Y]}]
, {i, 1, Length[X]}]
EDIT: The above code does not give the correct result. For $n=8$ the value should be 31449600, and the relevant OEIS sequence is https://oeis.org/A036981. Here is new code which should be correct, and is also much faster (it could be made even faster by exploiting the initial symmetry, but it's meant to be a brute-force script):
<< Combinatorica`
Leagues[adj_, 0] := 1
Leagues[adj_, 1] := Length[adj]
Leagues[adj_, n_] :=
(
graph = AdjacencyGraph[adj];
matchFound = False;
Do[
If[IsomorphicGraphQ[graph, CacheGraphs[n][[i]]],
matchFound = True;
val = CacheValues[n][[i]]]
, {i, 1, Length[CacheGraphs[n]]}];
If[matchFound, val,
val = Sum[row = adj[[i]];
itemCount = Total[row];
newItems = Table[0, {itemCount}];
j = 1;
Do[If[row[[k]] == 1, newItems[[j]] = k; j++], {k, 1,
Length[row]}];
newAdj = adj[[newItems, newItems]];
Leagues[newAdj, n - 1]
, {i, 1, Length[adj]}];
graph = AdjacencyGraph[adj];
AppendTo[CacheGraphs[n], graph];
AppendTo[CacheValues[n], val];
val]
)
Result[n_]:= (
X = Select[Involutions[n, Cycles], Length[#] == (n/2) &];
Do[CacheGraphs[m] = {};
CacheValues[m] = {}, {m, 1, n}]; Leagues[
Table[Boole[Intersection[X[[i]], X[[j]]] == {}], {i, 1,
Length[X]}, {j, 1, Length[X]}], n - 1])
With a few minutes of calculation it is able to also match the next term in the OEIS sequence, 444733651353600.
Incidentally, it seems the hardest part of the calculation in my new approach can be reduced to the graph isomorphism problem, which is not known to be in either P or NP-Complete.