Assumptions should always be for one of three purposes:
1) It's actually a premise. For example, $p \wedge q$ is a legal assumption in this case.
2) It's the beginning of a proof by contradiction (which I think in Fitch is "$\neg$-introduction"), in which case you are later going to "eliminate" the assumption.
3) It's the beginning of a subproof for proving an implication ($\rightarrow$-introduction), in which case you are later going to "eliminate" the assumption.
Whenever you make an assumption, you should think "if this is true, then..." You want to prove "if $p \wedge q$ then $q \vee r$", so you can assume $p \wedge q$. If you also assume $(p \wedge q) \rightarrow (q \vee r)$, then what you're proving is "if $p \wedge q$ and also $(p \wedge q) \rightarrow (q \vee r)$, then $q \vee r$."
The rules of Fitch, other than assumption, are all "Introduction" or "Elimination" of something. Think about which rules you have that can do things to $\wedge$, and which rules you have that can create a $\vee$. For example, from $p \wedge q$ I can derive $p$.
Also, think through why $q \vee r$ might follow from $p \wedge q$. Logic doesn't come from nowhere - it's just a math-y version of how you already deduce things. $p$, $q$, and $r$ all stand for sentences; try out an option. Say $p$ is the sentence "Bob has a hat", $q$ is the sentence "Jill is wearing shoes", and $r$ is the sentence "Joe is tall". Then $p \wedge q$ is the sentence "Bob has a hat AND Jill is wearing shoes". $q \vee r$ is the sentence "Either Jill is wearing shoes, OR Joe is tall. If I know that "Bob has a hat and Jill is wearing shoes", how do I know that "Either Jill is wearing shoes, or Joe is tall"? Well, it's because I know that Jill is wearing shoes, so it doesn't matter whether Joe is tall. In other words, the reason we can get $q \vee r$ from $p \wedge q$ has something to do with $q$, not $r$ or $p$. That might give you a clue on how to start.