You should think of $\Box$ and $\Diamond$ as saying something about the next "step" or transition in the Kripke model. $\Box \varphi$ says that in the next step, $\varphi$ will hold, regardless of which transition we pick. $\Diamond \varphi$ says that there is a transition in which $\varphi$ will hold, i.e. we can choose our next step such that $\varphi$ will hold.
Multiple connectives will therefore tell you something about multiple steps. For example, $\Diamond \Box \Diamond \varphi$ says that there exists a transition such that we end up in a world $w$, and for any transition we take from $w$, we will end up in a world where we can take some transition to where $\varphi$ holds. Hence, we know something about what happens three steps ahead.
For your specific example, let us relabel $x_4$ with $\{p,q\}$, as you say. The formula $\Box \neg \Box p$ says that any transition we take will take us to a world in which we can not reach a world that is labelled with $p$. However, this is clearly false for $x_4$: The only transition we can take is to $x_5$, and all the worlds reachable by $x_5$ (these are $x_4$ and $x_6$) are labelled with $p$.