Let's call $\sim_n$ the general relation $(x,y)\in\mathbb Z^2, x\sim_n y\iff |x-y|=n$.
Let's call $\thickapprox$ the reflexive-transitive closure of $\sim_1$.
To render $\sim_1$ reflexive, you are just interested by the domain of definition of this relation, this is $\mathbb Z$.
So we just say that $\forall x\in\mathbb Z, x\thickapprox x$.
There is no need for symetric closure, since $\sim_1$ is already symetric.
Nevertheless $\forall (x,y)\in\mathbb Z^2, x\thickapprox y\iff y\thickapprox x$
No, let's have a look at transitivity.
Let's call $E_n$ the subset of $\mathbb Z^2$ such that $(x,y)\in E_n\iff x\sim_n y$.
The first step of the transitive closure is to consider all elements of $U_0=E_1$ and make $\thickapprox$ transitive on this set.
So, if $(x,y),(y,z)\in (U_0)^2$ we want $(x\thickapprox y \text{ and } y\thickapprox z)\implies x\thickapprox z$.
But in $U_0=E_1,\quad x\thickapprox y$ is the same than $x\sim_1 y$ so
$|x-y|=1 \iff x=y+\epsilon_1$ where $\epsilon_1=\pm 1$
$|y-z|=1 \iff y=z+\epsilon_2$ where $\epsilon_2=\pm 1$
$x=z+\epsilon_1+\epsilon_2=z+\epsilon_3$ where $\epsilon_3\in\{-2,0,2\}$, thus $x\sim_0 z$ or $x\sim_2 z$.
Now we define $U_1=E_0\cup E_1\cup E_2$ and we have to make $\thickapprox$ transitive on this set.
I let you convince yourself that now $\epsilon_3=\epsilon_1+\epsilon_2$ can take the values $-4,-3,-2,-1,0,1,2,3,4$
The next set is $U_2=E_0\cup E_1\cup E_2\cup E_3\cup E_4$.
We have to continue the process until all possibilities are exhausted, and this lead to $U_\infty=\mathbb Z$.
Finally $\forall (x,y)\in\mathbb Z, x\thickapprox y\ $ and the closure of $\sim_1$ is not very interesting since there is only $1$ equivalence class.
Note 1: for $n\ge 2$ the closure of $\sim_n$ is a little more interesting, $x\thickapprox y$ if $x,y$ differ from a multiple of $n$, so there are $n$ equivalence classes.
Note 2: $\sim_0$ is already an equivalence relation, so it is its own closure, yet not very interesting either because $\mathbb Z/\sim_0=\mathbb Z$.
Note 3: I suppose you have now guessed that the closure of $\sim_n$ is the equality $\pmod{n}$.