I assume this is Big O for programming so $n\in\mathbb{N}$.
$r(n)=\left(\sqrt{n}+20\log_2(n)+\frac{n}{2}\right)(4n+\log(n)+5)$
$\Longrightarrow r(n)=4n\sqrt{n}+\log(n)\sqrt{n}+5\sqrt{n}+80n\log_2(n)+20\log(n)\log_2(n)+100\log_2(n)+2n^2+\frac{n}{2}\log(n)+\frac{5n}{2}$
Since $\exists c\in\mathbb{N}$ such that $\exists N_0\in\mathbb{N}$ and $\forall n\in\mathbb{N},~n\ge N_0,~r(n)\le c\cdot n^2\Longrightarrow r(n)\in O(n^2)$.
Prove:
$\begin{array}{rclc}
4n\sqrt{n} & \le & 4n^2 & (n\ge1)\\
\log(n)\sqrt{n} & \le & n^2 & (n\ge1)\\
5+\sqrt{n} & \le & 6n^2 & (n\ge1)\\
80n\log_2(n) & \le & 80n^2 & (n\ge1)\\
20\log(n)\log_2(n) & \le & 20n^2 & (n\ge1)\\
100\log_2(n) & \le & 100n^2 & (n\ge1)\\
2n^2 & \le & 2n^2 & (n\ge1)\\
\frac{n}{2}\log(n) & \le & n^2 & (n\ge1)\\
\frac{5n}{2} & \le & 3n^2 & (n\ge1)\\
\Longrightarrow r(n) & \le & 217n^2 & (n\ge1)
\end{array}$
So we can choose $c=217$ and $N_0=1$.
Also, $r(n)\in\Omega(n^2)$, since all functions in the sum are positive for $n\ge1$ then for $c=1$ and $N_0=1$ we have this trivial affirmation: $\forall n\in\mathbb{N}:n\ge N_0: c\cdot n^2\le r(n)$.
So $r(n)\in\theta(n^2)$ because $r(n)\in\Omega(n^2)~\wedge~r(n)\in O(n^2)$.