$$\begin{pmatrix}4\:&\:-5\:\\ \:\:-16\:&\:20\end{pmatrix}.\begin{pmatrix}a&b\\ \:\:\:c&d\end{pmatrix}=\begin{pmatrix}0&0\\ \:\:\:0&0\end{pmatrix}$$
I find this problem particularly confusing as you can not find the inverse of a $2 \times 2$ matrix.
$$\begin{pmatrix}4\:&\:-5\:\\ \:\:-16\:&\:20\end{pmatrix}.\begin{pmatrix}a&b\\ \:\:\:c&d\end{pmatrix}=\begin{pmatrix}0&0\\ \:\:\:0&0\end{pmatrix}$$
I find this problem particularly confusing as you can not find the inverse of a $2 \times 2$ matrix.
You could find the inverse of the first $2\times 2$ matrix if it were invertible, but it is not. Therefore, there is some nontrivial linear combination of its columns which is equal to the $0$ vector. Since the second column is just $-5/4$ the first column, we might consider $[1,4/5]^{T}$, and observe that this indeed gives $0$ if we multiply the first matrix by this vector. Then for any nonzero $a$ and any $b$, the matrix $$\begin{bmatrix} a&b\\ (4/5)a&(4/5)b\end{bmatrix}$$ is nonzero and has the desired property.
Hint:
note that $$4 (5) -5(4) =0$$
Can you use this information to set $a,b,c,d$ to satisfy the matrix equation?
You might want to solve this problem first. $$\begin{pmatrix}4\:&\:-5\:\\ \:\:-16\:&\:20\end{pmatrix}.\begin{pmatrix}a\\ c\end{pmatrix}=\begin{pmatrix}0\\0\end{pmatrix}$$