First let me point out that I realise this is a subjective question, and so it doesn't follow the general guidelines for "a good question on MSE". However, I have read through the guidelines for "what makes a subjective question good" and I believe this question fits the mould.
"What is the biggest distinction in all of mathematics?"
In the abstract for a public lecture which will be occurring at my university soon, the speaker claimed that "the difference between discrete and continuous is the biggest distinction in all of maths". I believe this statement is meaningless, because they aren't mutually exclusive. For example, any function mapping between discrete spaces is automatically continuous.
I believe what the speaker was essentially trying to say was, "the biggest distinction in maths is whether a space is discrete or complete (in the metric sense)". But now if you try to capture the essence of the statement by abstracting it to a topological setting, it's like saying "the biggest distinction in maths is the discrete topology vs the trivial topology", which seems nonsensical. Almost nobody uses those topologies. Besides, there are so many other fields of maths, like logic or group theory or graph theory that barely mention topology at all.
My question is, is there a reasonable answer to the question "what is the biggest distinction in all of mathematics?" If so, what could it be, and why does it fit that description? If not, why not?
(I'm leaning towards "there is no answer to the question", but my only reasoning is that "maths is simply just too broad", which isn't a strong enough argument.)