There are some things you can test...
Full Rank
If the matrix is not of full rank, it has a non-trivial kernel. Hence there exists a vector $v$ such that $Av=0$ and thus $v^\top Av=0$. And therefore $A$ is not positive definite.
An easy way to test this, is linear dependence of the rows / columns.
Eigenvalues
If $A$ is symmetric/hermitian and all eigenvalues are positive, then the matrix is positive definite.
Main Diagonal Elements
Because of $a_{ii}=e_i^\top Ae_i>0$ all main diagonal entries have to be positive. If not the matrix is not positive definite.
Gerschgorin Circles
This is a cool criterion, that you usually don't learn in linear algebra. Consider the circle disks
$$K^i:= K_{r_i}(a_{ii})⊂ℂ$$
with midpoint $a_{ii}$ and radius $r_i = \sum_{j\neq i}|a_{ij}|$.
All eigenvalues of $A$ are in the union of these disks.
Again you can tell something about the eigenvalues. E.g. if $A$ is symmetric, $a_{ii}>0$ and $a_{ii}>r_i$ all circles are in the right half of the complex plane, and thus $A$ is positive definite. [keyword diagonal dominance]
Note, that you can also compute the circles for $A^\top$.
Hurwitz criterion
The north-west minors of a matrix $A$ are the determinants of the sub-matrices
$$ H_1 = \pmatrix{a_{11}}, \qquad H_2=\pmatrix{a_{11} & a_{12} \\ a_{21} & a_{22}}, \qquad H_3=\pmatrix{a_{11} & a_{12} & a_{13} \\ a_{21} & a_{22} & a_{23} \\ a_{31} & a_{32} & a_{33}} \qquad ...$$
If $\det(H_i)>0$ for all $i=1,…,n$ then $A$ is positive definite. If they have alternating sign $\det(H_i)=(-1)^ia$, with $a>0$, then $A$ is negative definite.
Note that this is very expensive to compute.
Addition of Transpose
It is $v^TAv=(v^TAv)^T=v^TA^Tv$. And therefore $$2 v^\top A v = v^\top Av + v^\top A^\top v = v^\top(A+A^\top)v,$$
So, $A$ is positive definite if, and only if, $A+A^\top$ is positive definite.
Since $A+A^\top$ is symmetric it might be easier to check for positive definiteness.