Ah, I only now realized the question was asked before. To atone for my repost sin, I'll give an answer that I hadn't seen around and seems to me to be likely what the problem aims at (inspired by the substitution proposed in the other answers), please do check that it is correct:
Using the $(a+b)=x,(b+c)=y,(a+c)=z$ substitution, we have
$$
\begin{vmatrix}
y-x-z & x & z\\
x & z-x-y & y \\
z & y & x-y-z \\
\end{vmatrix}
$$
Now $R1=R1+R2+R3$:
$$
\begin{vmatrix}
y & z & x\\
x & z-x-y & y \\
z & y & x-y-z \\
\end{vmatrix}
$$
Now you multiply column 1 by $xz$, column 2 by $xy$ and column 3 by $yz$, in order to make $xyz$ across the row. To compensate you put $\frac{1}{(xyz)^2}$ in front:
$$\frac{1}{(xyz)^2} \begin{vmatrix}
xyz & xyz & xyz\\
x^2z & xy(z-x-y) & y^2z \\
z^2x & xy^2 & yz(x-y-z) \\
\end{vmatrix}$$
Now you take out $xyz$ from the first row and do $C2=C2-C1$, $C3=C3-C1$, and you get something like:
$$\frac{1}{(xyz)} \begin{vmatrix}
1 & 0 & 0\\
... & ... & ... \\
... & ... & ... \\
\end{vmatrix}$$
Where $...$ stands in for polynomials I don't really want to write out, but you can see only one 2x2 determinant survives, which when expanded should yield the desired $4x^2y^2z^2$, which then divides by $xyz$ to get the result $4xyz$.