I apply a one-to-one continuation of Jack D'Aurizio's answer to your (-;) question in here.
Let $p(x)$ be a polynomial with degree $d\geq 1$, and let $\delta$ be the (difference) operator mapping $p(x)$ into $p(x)-p(x-1)$. Then $(\delta p)(x)$ is a polynomial with degree $d-1$. We have that
$$(\delta^n p)(x) = \sum_{k=0}^{n}(-1)^k \binom{n}{k} p(x-k) \tag{1}$$
The sum you ask for is the RHS of $(1)$ in the case $p(x)=(x+n)^{n}$. So the original polynomial had degree $d=n$, hence $(1)$ has degree $n-n=0$ in $(x+n)$ which is to say that the result is the sum of all terms with power zero of $(x+n)$. This is given as
$$
\sum_{k=0}^{n}(-1)^k \binom{n}{k} (-k)^n= (-1)^n \sum_{k=0}^{n}\binom{n}{k} (-1)^k \frac{\partial^n}{(\partial a)^n}\exp (ak) |_{a=0} \\
= (-1)^n \lim_{(a \to 0)}\frac{\partial^n}{(\partial a)^n} \sum_{k=0}^{n}\binom{n}{k} (-e^a)^k = \lim_{(a \to 0)}\frac{\partial^n}{(\partial a)^n} (e^a-1)^n \\
= \lim_{(a \to 0)}\frac{\partial^n}{(\partial a)^n} a^n(1 +a/2 + \dots )^n = \lim_{(a \to 0)}\frac{\partial^n}{(\partial a)^n} a^n = n!
$$
where in the last line, after expansion of the exponential, the fact was used that only terms with $a^n$ survive the operator $\lim_{(a \to 0)}\frac{\partial^n}{(\partial a)^n}$.
This proves the claim. $\qquad \Box$