The background story here is that your field is a splitting field of the polynomial $(x^2-2)(x^2-3)$, and as such the Galois group $\operatorname{Gal}(\mathbb Q(\sqrt 2, \sqrt 3):\mathbb Q)$ acts on it. It turns out that this group has four elements:
- $I$: Identity,
- $\Phi_2$: Automorphism that maps $\sqrt 2$ to $-\sqrt 2$ but leaves $\sqrt 3$ in place,
- $\Phi_3$: Automorphism that maps $\sqrt 3$ to $-\sqrt 3$ but leaves $\sqrt 2$ in place,
- $\Phi_6$: Automorphism that maps $\sqrt 2$ to $-\sqrt 2$ and $\sqrt 3$ to $-\sqrt 3$.
Now, for an element $x=a+b\sqrt 2+c\sqrt 3+d\sqrt 6$, its conjugates are defined as the maps of $x$ using all those automorphisms. In our case, what you will get is:
- $I(x)=x=a+b\sqrt 2+c\sqrt 3+d\sqrt 6$
- $\Phi_2(x)=a-b\sqrt 2+c\sqrt 3-d\sqrt 6$
- $\Phi_3(x)=a+b\sqrt 2-c\sqrt 3-d\sqrt 6$
- $\Phi_6(x)=a-b\sqrt 2-c\sqrt 3+d\sqrt 6$
The product of all those: $N(x)=I(x)\Phi_2(x)\Phi_3(x)\Phi_6(x)$ must be mapped into itself by all those automorphisms, because those automorphisms make up a group. For example,
$$\Phi_2(N(x))=\Phi_2(I(x))\Phi_2(\Phi_2(x))\Phi_2(\Phi_3(x))\Phi_2(\Phi_6(x))=\Phi_2(x)I(x)\Phi_6(x)\Phi_3(x)=N(x)$$
And similar for $\Phi_3$ and $\Phi_6$.
Thus, as the Galois theory teaches us, $N(x)$ belongs to the field fixed by all the automorphisms, which coincides with $\mathbb Q$. In other words, $N(x)$ is always rational.
Moral: if $x=a+b\sqrt 2+c\sqrt 3+d\sqrt 6$, with $a,b,c,d$ rational: to find $\frac{1}{x}$, multiply both the numerator and denominator by $\Phi_2(x)\Phi_3(x)\Phi_6(x)=(a-b\sqrt 2+c\sqrt 3-d\sqrt 6)(a+b\sqrt 2-c\sqrt 3-d\sqrt 6)(a-b\sqrt 2-c\sqrt 3+d\sqrt 6)$.
Edited to add: Wolfram Alpha has calculated for me that you will end up with the following in the denominator:
$$a^4 - 4 a^2 b^2 - 6 a^2 c^2 - 12 a^2 d^2 + 48 a b c d + 4 b^4 - 12 b^2 c^2 - 24 b^2 d^2 + 9 c^4 - 36 c^2 d^2 + 36 d^4$$
(yep, I know, it's horrid, but it is rational!)