1. Sums over the grid.
The sum of the first $n$ odd numbers is actually $n^2$:
$$1+3+5+\ldots+(2n-3)+(2n-1)=\sum^n_{k=1} (2k-1) = n^2.$$
Moreover, you can express any odd number as a difference of squares: $$2n-1=n^2-(n-1)^2.$$ Or any sum of consecutive odd numbers for that matter: $$\sum^n_{k=m} (2k-1) = \left(\sum^n_{k=1} -\sum^{m-1}_{k=1}\right) (2k-1) = n^2 -(m-1)^2.$$
Or even better: the sum of the first $n$ cubes equals the squared sum of the first $n$ integers:
$$1^3+2^3+3^3+\ldots+(n-1)^3+n^3 =\sum_{k=1}^n k^3 =\left(\sum_{k=1}^n k\right)^2 =\frac{n^2(n+1)^2}{4}.$$
This can also be seen on a grid:
from: https://upload.wikimedia.org/wikipedia/commons/2/26/Nicomachus_theorem_3D.svg
Here's more. If you have a sum over a square grid (as in assigning each tile a number), you can compute the same sum over just (a triangular) half of the whole region (plus the diagonal strip):
Let $S=\{1,2,3,\ldots,n\}$. Let $f:S\times S\to$ any field. Then
$$\sum_{x=1}^n \ \sum_{y=1}^n f(x,y) = \sum_{x=1}^n \left(f(x,x) +\sum_{y=1}^{x-1} \big(f(x,y)+f(y,x)\big)\right)$$ when the sums are finite.
This is easier to see with integrals: let $g:[0,1]\times[0,1]\to[a,b]\subsetneq\mathbb{R}$, then $$\int^1_0\int^1_0 g(x,y)\ \text{d}y\ \text{d}x=\int^1_0\int^x_0\big(g(x,y)+g(y,x)\big)\ \text{d}y\ \text{d}x.$$
If you place an origin at the centre of your grid, you can also divide the grid in four square smaller grids, or eight triangular grids.

2. Spirals on the grid.
You can also draw square spirals on the grid, such as Ulam's.
3. Golden rectangles.
Consider drawing squares on the grid following this pattern (starting at the upper $1$ tile):

Applications aside, the numbers $1, 1, 2, 3, 5, 8, 13, \ldots$ are the Fibonacci sequence. Look at the outer rectangle: the more squares you add to it, the closer the ratio of its side lengths gets to the golden ratio $1.618$.
4. Computer screens.
The screen you are reading right now is just a huge grid of tiny little dot lights. Computers can't represent continuous stuff, so they approximate continuous with small straight lines made up of square points (pixels). Hopefully, it gives the optical ilusion of continuous smooth curves when seen from afar. This is mathematically relevant as of the use of graphicators.
5. Games/problems that rely heavily on grids:
Chess, checkers, sudokus, magic squares, "squaring the square" (tiling an integral square using only other integral squares), crosswords, pixel art, nonograms, Battleship, Dungeons and Dragons, most $2$D Super Mario Bros. videogames, tic-tac-toe, Connect $4$, lines and dots, Tetris, among others.