There is an expression for $\mathbb E[x_1x_2]^2$ in which $\mathbb Ex_1^2$ and $\mathbb Ex_2^2$ are present. See the answer of Tony for instance, and also you could "use":$$\mathbb E[x_1x_2]^2=\mathbb E[x_1x_2]^2-\mathbb Ex_1^2-\mathbb Ex_2^2+\mathbb Ex_1^2+\mathbb Ex_2^2$$
But purely an expression in terms of $\mathbb Ex_1^2$ and $\mathbb Ex_2^2$ and nothing else? No!
Suppose that there would indeed be some expression:$$\mathbb E[x_1x_2]^2=f(\mathbb Ex_1^2,\mathbb Ex_2^2)$$
Then e.g. if $x_1,x_2$ are iid then we would find:$$\mathbb Ex_1^4=\mathbb E[x_1x_1]^2=f(\mathbb Ex_1^2,\mathbb Ex_1^2)=f(\mathbb Ex_1^2,\mathbb Ex_2^2)=\mathbb E[x_1x_2]^2=\mathbb Ex_1^2\mathbb Ex_2^2=[\mathbb Ex_1^2]^2$$
or equivalently $\mathsf{Var}(x_1^2)=0$ so that $x_1^2$ is degenerated.
So the existence of such expressions allows us to prove that for all random variables $x_1$ that have finite $4$-th moment the random variable $x_1^2$ is degenerated (which is absurd).