Assume that 3-manifold $M$ is embedded in 1-connected 4-manifold $N$ and it separates it onto two manifolds $N_1,N_2$ with boundary. In such case from Mayer-Vietoris we have:
$H_2N\to H_1M\to H_1N_1\oplus H_1N_2 \to H_1N $
If $N$ is also 2-connected then $H_1M$ is isomorphic to above sum of $H_1N_1\oplus H_1N_2$. From another algebraic machinery called "universal coefficient theorem" we get that torsion subgroup of $H_1N_1$ is equal to torsion of $H_1N_2$. In this case manifold $N$ is homology sphere.
Can we somehow for chosen manifold $M$ decide on when it is embeddable in homology sphere $N$ or not ? It is probably not easy problem. One condition is that torsion group is of shape $G+G$. I just wonder how I can continue from this point further.
On the other hand is it known procedure for embedding any 3-manifold into 1-connected 4-manifold ?
EDIT 2018-10-05
I would like to add more details about my reasoning. Imagine manifold $M$ is embedded in $R^5$ - every 3-manifold can be embedded there. Assume it is defined by equations $\{f=0,g=0\}$ for smooth real functions $f,g$. Now I would like to embed manifold $M$ into manifold $N^4$ as simple as possible. Is such $N$ exist in $R^5$ ? Yes, we can take e.g. $\{f=0\}$. It seems to me that we can find $N$ 1-connected. Consider following argument. If there is essential loop in $N$ not intersecting $M$ then it can be removed via surgery. The essential loop cannot intersect $M$ in one point, since $M$ separates $N$ (to be fiugred out why). If essential loop intersect $M$ in two points then we can represent it as product of two loops - each in different component of $N$. we can remove these loops via surgery on $N_1$ and $N_2$. I assume that these surgeries can be considered as embedded in $R^5$.
Now the idea is investigate manifold $M$ by possible 1-connected $N$s which can embrace it. The 4-manifolds considered are the ones embeddable in $R^5$ and 1-connected. Do we know anything about such class of 4-manifolds ?
Related ideas are following.
- Apply physics of minimal soap surface. It works for circle in $R^3$. Can it work for 3-manifold in $R^5$ ? We can assume that $M$ is not knotted.
- For given $M\subset S^4$ having Betti number $r$ and torsion $G$ splitting sphere onto $N_1,N_2$ what are possibilities for homology of $N_1$ and $N_2$ ?.
- Is it known when 1-connected 3-complex $K$ is embeddable in $R^5$ ? Boundary of tubular neighborhood of $K$ is 1-connected 4-manifold $N$ with $\pi_2$ the same as $K$ (we select only such $K$ that $N$ is 1-connected).
Thank you for response from Mike Miller.