The last digit of $37^{100}$ is the same as the last digit of $7^{100}$ or of $492038497^{100}$.
When you multiply two positive integers, the last digit in the product depends on those two integers only through their last digits. That will become obvious if you look at the way they told you to multiply numbers by hand in third or fourth grade or whenever it was:
$$
\begin{array}{rrrrrrrrrr}
& & & 4 & 2 & 7 \\
& & \times & 3 & 1 & 9 \\
\hline
& & \bullet & \bullet & \bullet & 3 \\
& & \bullet & \bullet & \bullet \\
\bullet & \bullet & \bullet & \bullet \\
\hline
\bullet & \bullet & \bullet & \bullet & \bullet & 3
\end{array}
$$
Where did that last $3$ come from??
Now multiply $7$, and discard all but the last digit:
\begin{align}
7 \times 7 & & & = \cdots\ 9 \\
7 \times 7 \times 7 & = (\cdots\ 9\times 7) & &= \cdots \bullet \\
7 \times 7 \times 7 \times 7 & = (\cdots \bullet\times 7) & & = \cdots \bullet \\
7 \times 7 \times 7 \times 7 \times 7 & = (\cdots \bullet\times 7) & & = \cdots\bullet \\
\end{align}
Just throw away all but the last digit at each step.
Now notice something: There are only $9$ digits that could possibly appear as the last digit (you can't get $0$ when you're multiplying non-zero digits). That means you can't keep getting new digits there that you haven't seen before.
All this will lead you to see a pattern that occurs as you continue the process. And you'll see why that happens. And that will lead you quickly to the answer.