I sort of doubt there is a good one out there, but I thought I'd ask. I'm looking for a mnemonic for the general discriminant of the polynomial $ax^3+bx^2+cx+d$, which is
$$b^2c^2-4ac^3-4b^3d-27a^2d^2+18abcd$$
Obviously if necessary, one can use different letters and / or assume a=1. However, the expression is homogeneous with respect to the coefficients, so it might be easier to leave $a$ in.
A much easier case is the discriminant of $x^3+px+q$, which has discriminant $-4p^3-27q^2$.