Let $\mathbf{Grpd}$ and $\mathbf{Cat}$ be respectively the 2-categories of small groupoids and of small categories. At the 1-categorical level, the inclusion $\mathbf{Grpd}\rightarrow\mathbf{Cat}$ has a right adjoint, namely the core. Thinking about the definition of the core of a category, I don't think that there is a way of extending it to natural transformations, essentially because if I have two functors $F, G: \mathcal{C}\rightarrow\mathcal{D}$ and a natural transformation $\alpha: F\Rightarrow G$, $core(\alpha) : core(F)\Rightarrow core(G)$ should be a natural isomorphism, and it is easy to find examples for which this cannot be true (one could be the determinant).
So my question is: does the inclusion $\mathbf{Grpd}\rightarrow\mathbf{Cat}$ have a right biadjoint? My impression is that the answer should be no, but I don't know how to prove this.