Let $X$ and $Y$ be topological spaces. A homotopy from a continuous function $f: X \to Y$ to a continuous function $g: X \to Y$ is a continuous function $H : X \times [0, 1] \to Y$ such that $H(x, 0) = f(x)$ and $H(x, 1) = g(x)$ for all $x \in X$. An isotopy is a homotopy such that $H(\cdot, t)$ is an embedding for every $t \in [0, 1]$; isotopy requires $f$ and $g$ to be embeddings.
Suppose $X = \{x \in \mathbb{R}^n : \sum_{i = 1}^n x_i^2 < 1\}$ is the open $n$-ball, and let $f, g : X \to Y$ be homeomorphisms. Does there always exist an isotopy from $f$ to $g$?
Alexander's trick solves a similar problem, but on closed $n$-balls.