It's false generally, but true in some cases. I don't have a full characterization of when it's true. Consider Titu's Lemma (a consequence of the Cauchy-Schwartz inequality. See the Cauchy-Schwartz wikipedia page).
$$\frac{(\sum_{k=1}^M u_k)^2}{\sum_{k=1}^M v_k} \leq \sum_{k=1}^M\frac{u_k^2}{v_k}.$$
If $A_k = u_k = 1$ and $B_k = v_k$ for all $k$, then we're done. This implies
$$M\frac{M}{\sum_{k=1}^M B_k} \leq \sum_{k=1}^M \frac{1}{B_k}.$$
Now for a specific counterexample. Let $A_1 = 20200$ and $A_k=1$ for $k=2,\dots,11$. Let $B_1 = 10000$ and $B_k = 10$ for $k=2,\dots,11$. Of course, $M=11$. Then,
\begin{align*}
&\frac{\sum_{k=1}^M A_k}{\sum_{k=1}^M B_k} = \frac{20210}{10100} \geq 2.\\
&\frac{1}{M}\sum_{k=1}^M\frac{A_k}{B_k} = \frac{1}{11}\left(2.02 + 10*0.1\right) = \frac{3.02}{11} < 1.
\end{align*}
I just chose some extreme numbers to make an example. You could probably construct a cleaner counterexample later. Here's how I constructed it. Start with arbitrary positive $B_k$ (assume the $B_k$ are not all equal to each other.) and let $A_k = 1$ for all $k$. In this case, we know the inequality holds. Then take the partial derivatives with respect to $A_k$ for some $k$ such that $B_k > \overline{B}:=\frac{1}{M}\sum_{k=1}^M B_k$. Then the derivative on the left side of the inequality is $\frac{1}{M\overline{B}}$ and the derivative on the right side of the inequality is $\frac{1}{MB_k} < \frac{1}{M\overline{B}}$. So for a counterexample, make $A_k$ large if $B_k$ is large.