By symmetry, we can assume $x \ge y$ and then duplicate the solutions. A simple way to to note that $20 \lt x \le 80$ to make the sum large enough and not too large. That is only $60$ numbers to try. A spreadsheet with copy down will make it easy, finding the pair (45,180).
Another way to find it is to note $\frac 1{\sqrt{20}}=\frac 1{2\sqrt 5}$ and remember that $\frac 13+\frac 16=\frac 12$, again giving $(45,180)$ and $\frac 14+\frac 14=\frac 12$ giving $(80,80)$
The algebraic approach is a mess.
$$\frac 1{\sqrt x}+\frac 1{\sqrt y}=\frac 1{\sqrt {20}}\\
\frac 1{\sqrt x}=\frac 1{\sqrt {20}}-\frac 1{\sqrt y}\\
\frac 1x=\frac 1{20}-\frac 2{\sqrt{20y}}+\frac 1y\\
\frac 1x-\frac 1y-\frac 1{20}=\frac 1{\sqrt{20y}}\\
\frac 1{x^2}+\frac 1{y^2}+\frac 1{400}-\frac 2{xy}-\frac 1{10x}+\frac 1{10y}=\frac 1{20y}\\
400y^2+400x^2+x^2y^2-800xy-40xy^2+40x^2y=20x^2y$$
but at least we can note that $x^2y^2$ must have a factor of $20$, so either one has a factor $10$ or one has a factor $2$ and the other a factor $5$. We can view this as a quadratic in one of the variables and feed it to the quadratic equation, but that will lead to testing cases in a more complicated way.