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Is there a way to make a $4\times4$ matrix composed of Pauli/Identity matrices that has determinant equal to $1$? Something of a general formula? It's interesting to me.

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No, out of the $256$ possible $4\times 4$ block matrices that you can obtain from matrices of the form $$ \begin{pmatrix} 1&0\\ 0&1 \end{pmatrix},\,\,\, \begin{pmatrix} 0&1\\ 1&0 \end{pmatrix},\,\,\, \begin{pmatrix} 0&-i\\ i&0 \end{pmatrix},\,\,\, \begin{pmatrix} 1&0\\ 0&-1 \end{pmatrix} $$ there are only $6$ possible determinant values, namely $0,-2,2,-2i,2i$ and $4$. Informally speaking, it is not hard to write a small code to check this.

sam wolfe
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