$$p ↑ q\equiv\overline{p}+\overline{q}\equiv \neg p\lor\neg q\tag*{aka Nand}$$
And the fully simplified solution should be:
$$(\overline{x}↑y)↑z$$
Basicly, first try to express the statement in form of $\overline{p}+\overline{q}$, to get this we need De Morgan's law:
Boolean algebra notation:
\begin{align}
\overline{x}y+\overline{z}\tag*{$\text{De Morgan's law}$}
&\equiv\overline{\overline{\overline{x}}+\overline{y}}+\overline{z}\\
&\equiv\overline{\overline{x}↑y}+\overline{z}\\
&\equiv(\overline{x}↑y)↑z\\
\end{align}
PL notation:
\begin{align}
(\neg x\land y) \lor \neg z\tag*{$\text{De Morgan's law}$}
&\equiv\neg(\neg\neg x\lor \neg y)\lor\neg z\\
&\equiv\neg(\neg x↑y)\lor \neg z\\
&\equiv(\neg x↑y)↑z\\
\end{align}
First use De Morgan's law backward, so the statement is in form of $\overline{p}+\overline{q},$
and the last two line is just substitute the definition.
Therefore we simplified it with Nand.