The asymptotes of a hyperbola pass through the corners of a rectangle whose sides are its transverse and conjugate axes. In particular, for a hyperbola with equation
$$\frac{x^2}{a^2}-\frac{y^2}{b^2}=1 \tag{1}$$
the asymptotes pass through the points $(\pm a, \pm b)$, so their slopes are
$$m = \pm\frac{b}{a} \tag{2}$$
A rectangular hyperbola is one in which the transverse and conjugate axes match: $a=b$. Correspondingly, by $(2)$ the asymptotes have slopes
$$m = \pm \frac{a}{a} = \pm 1 \tag{3}$$
Lines with slopes $+1$ and $-1$ are are perpendicular (after all, $(+1)\cdot(-1)=-1$), so formula $(2)$ is consistent with the fact that rectangular hyperbolas have perpendicular asymptotes.
conic-sections. – Blue Dec 21 '19 at 11:48