Let consider a simple equation $$I = \frac{V_1-V_2}{R}$$ with $R = 0.001$ and $V_1, V_2$ around $10\ 000$, while $I$ is around $10$. The problem is $V_1$ and $V_2$ are measured with some small error (compared to $10\ 000$ as nominal value) of around $5$. But this small error will lead to unacceptable big error in $I$, when we get $$I = \frac{V_1-V_2}{R}. $$
How can we solve this problem? when we have $I$, $V_1$ and $V_2$ are continuously changing with time. how we can get a good estimate of $I$ with $V_1$ and $V_2$ measurement. Thank you very much!