We can use $\lim\limits_{x\to 0} \dfrac{\tan x}{x}= 1$ and
$$\tan(a-b)=\frac{\tan a-\tan b}{1+\tan a\tan b}$$
to get rid of the $\arctan$s:
$$\begin{aligned} \lim_{x\to 2} \frac{\arctan x^2-\arctan 4}{\tan 2^x-\tan 4}
&= \lim_{x\to 2} \left[\frac{\arctan x^2-\arctan 4}{\tan(\arctan x^2-\arctan 4)}\cdot \frac{\tan(\arctan x^2-\arctan 4)}{\tan 2^x-\tan 4}\right]\\
&= \lim_{x\to 2}\frac{\tan(\arctan x^2-\arctan 4)}{\tan 2^x-\tan 4}\\
&= \lim_{x\to 2} \frac{\frac{x^2-4}{1+4x^2}}{\frac{\sin2^x\cos 4-\sin 4\cos2^x}{\cos^{2^x}\cos 4}}\\
&=\frac{\cos^2 4}{17} \cdot \lim_{x\to 2}\frac{x^2-4}{\sin(2^x-4)}
\end{aligned}
$$
and:
$$
\begin{aligned}
\lim_{x\to 2}\frac{x^2-4}{\sin(2^x-4)} &= \lim_{x\to 2} \frac{x^2-4}{2^x-4} \cdot \lim_{x\to 2} \frac{2^x-4}{\sin(2^x-4)}\\
&=\lim_{x\to 2} \frac{x^2-4}{2^x-4}\\
&= \lim_{x\to 2} \frac{x+2}{4} \cdot \lim_{x\to 2} \frac{x-2}{2^{x-2}-1}\\
&=1\cdot \frac{1}{\ln 2}
\end{aligned}
$$
At the end, I used $\lim\limits_{x\to 0} \dfrac{a^x-1}{x}=\ln a$. Thus, the final answer is $\dfrac{\cos^2 4}{17 \ln 2}$.