Dividing top & bottom by $2$ and fairly directly integrating your original integral gives
$$\begin{equation}\begin{aligned}
\int \frac{2x}{2x+4} dx & = \int \frac{x}{x+2} dx \\
& = \int \frac{x + 2 - 2}{x+2} dx \\
& = \int \left(1 - \frac{2}{x + 2}\right) dx \\
& = x - 2\ln|x + 2| + C_1
\end{aligned}\end{equation}\tag{1}\label{eq1A}$$
Note I effectively did polynomial division where I used that $x = x + 2 - 2$ in the numerator in the second line. Next, using your substitution of $u = 2x + 4$ gives $du = 2dx \implies dx = \frac{du}{2}$. Thus, you then get
$$\begin{equation}\begin{aligned}
\int \frac{2x}{2x+4} dx & = \frac{1}{2}\int \frac{u - 4}{u}du \\
& = \frac{1}{2}\int \left(1 - \frac{4}{u}\right)du \\
& = \frac{1}{2}\left(u - 4\ln|u|\right) + C_2 \\
& = \frac{1}{2}\left((2x + 4) - 4\ln|2x + 4|\right) + C_2 \\
& = x + 2 - 2\ln|2(x + 2)| + C_2 \\
& = x - 2(\ln|x + 2| + \ln(2)) + 2 + C_2 \\
& = x - 2\ln|x + 2| + (2\ln(2) + 2 + C_2)
\end{aligned}\end{equation}\tag{2}\label{eq2A}$$
Note you made a small mistake in your question text where you used $dx$ instead of $du$. As you can see, you get the same result, with $C_1$ from \eqref{eq1A} being equal to $2\ln(2) + 2 + C_2 = \ln(4) + 2 + C_2$ from \eqref{eq2A}, so using substitution does work.
There's no reason why you can't use substitution. Instead, as several question comments have indicated, it's fairly likely your review notes stated to use polynomial division for you to practice that technique instead.